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Examining the Role of the HIV-1 Reverse Transcriptase p51 Subunit in Positioning and Hydrolysis of RNA/DNA Hybrids

Recent crystallographic analysis of p66/p51 human immunodeficiency virus (HIV) type 1 reverse transcriptase (RT) complexed with a non-polypurine tract RNA/DNA hybrid has illuminated novel and important contacts between structural elements at the C terminus of the noncatalytic p51 subunit and the nuc...

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Detalhes bibliográficos
Main Authors: Chung, Suhman, Miller, Jennifer T., Lapkouski, Mikalai, Tian, Lan, Yang, Wei, Le Grice, Stuart F. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668773/
https://ncbi.nlm.nih.gov/pubmed/23595992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.465641
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