Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

Vinylogous ureas 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide and N-[3-(aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-furancarboxamide (compounds 1 and 2, respectively) were recently identified to be modestly potent inhibitors of the RNase H activity of HIV-1 and HIV-2 reverse trans...

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Detalhes bibliográficos
Main Authors: Chung, Suhman, Wendeler, Michaela, Rausch, Jason W., Beilhartz, Greg, Gotte, Matthias, O'Keefe, Barry R., Bermingham, Alun, Beutler, John A., Liu, Shixin, Zhuang, Xiaowei, Le Grice, Stuart F. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935023/
https://ncbi.nlm.nih.gov/pubmed/20547794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00434-10
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