HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors

Por Beilhartz, Greg L., Götte, Matthias
Publicado em 2010

N348I in HIV-1 Reverse Transcriptase Can Counteract the Nevirapine-mediated Bias toward RNase H Cleavage during Plus-strand Initiation

Por Biondi, Mia J., Beilhartz, Greg L., McCormick, Suzanne, Götte, Matthias
Publicado em 2010

HIV-1 Reverse Transcriptase Can Simultaneously Engage its DNA/RNA Substrate at both the DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

Por Beilhartz, Greg L., Wendeler, Michaela, Baichoo, Noel, Rausch, Jason, Le Grice, Stuart, Götte, Matthias
Publicado no J Mol Biol (2009)

Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation

Por Beilhartz, Greg L., Ngure, Marianne, Johns, Brian A., DeAnda, Felix, Gerondelis, Peter, Götte, Matthias
Publicado em 2014

Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore

Por Zhang, Zhifen, Park, Minyoung, Tam, John, Auger, Anick, Beilhartz, Greg L., Lacy, D. Borden, Melnyk, Roman A.
Publicado em 2014

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

Por Tam, John, Hamza, Therwa, Ma, Bing, Chen, Kevin, Beilhartz, Greg L., Ravel, Jacques, Feng, Hanping, Melnyk, Roman A.
Publicado no Nat Commun (2018)

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanis...

Por Ehteshami, Maryam, Beilhartz, Greg L., Scarth, Brian J., Tchesnokov, Egor P., McCormick, Suzanne, Wynhoven, Brian, Harrigan, P. Richard, Götte, Matthias
Publicado em 2008

Impact of Primer-induced Conformational Dynamics of HIV-1 Reverse Transcriptase on Polymerase Translocation and Inhibition

Por Auger, Anick, Beilhartz, Greg L., Zhu, Siqi, Cauchon, Elizabeth, Falgueyret, Jean-Pierre, Grobler, Jay A., Ehteshami, Maryam, Götte, Matthias, Melnyk, Roman A.
Publicado em 2011

Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

Por Chung, Suhman, Wendeler, Michaela, Rausch, Jason W., Beilhartz, Greg, Gotte, Matthias, O'Keefe, Barry R., Bermingham, Alun, Beutler, John A., Liu, Shixin, Zhuang, Xiaowei, Le Grice, Stuart F. J.
Publicado em 2010

Derivatives of Mesoxalic Acid Block Translocation of HIV-1 Reverse Transcriptase

Por Bernatchez, Jean A., Paul, Rakesh, Tchesnokov, Egor P., Ngure, Marianne, Beilhartz, Greg L., Berghuis, Albert M., Lavoie, Rico, Li, Lianhai, Auger, Anick, Melnyk, Roman A., Grobler, Jay A., Miller, Michael D., Hazuda, Daria J., Hecht, Sidney M., Götte, Matthias
Publicado no J Biol Chem (2015)