Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation

Por Beilhartz, Greg L., Ngure, Marianne, Johns, Brian A., DeAnda, Felix, Gerondelis, Peter, Götte, Matthias
Publicado em 2014

The Activity of the Integrase Inhibitor Dolutegravir Against HIV-1 Variants Isolated From Raltegravir-Treated Adults

Por Underwood, Mark R., Johns, Brian A., Sato, Akihiko, Martin, Jeffrey N., Deeks, Steven G., Fujiwara, Tamio
Publicado em 2012

Novel cleavage of reductively aminated glycan-tags by N-bromosuccinimide to regenerate free, reducing glycans

Por Song, Xuezheng, Johns, Brian A., Ju, Hong, Lasanajak, Yi, Zhao, Chunmei, Smith, David F., Cummings, Richard D.
Publicado no ACS Chem Biol (2013)

Pharmacovirological Impact of an Integrase Inhibitor on Human Immunodeficiency Virus Type 1 cDNA Species In Vivo

Por Goffinet, Christine, Allespach, Ina, Oberbremer, Lena, Golden, Pamela L., Foster, Scott A., Johns, Brian A., Weatherhead, Jason G., Novick, Steven J., Chiswell, Karen E., Garvey, Edward P., Keppler, Oliver T.
Publicado em 2009

Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Comple...

Por Hightower, Kendra E., Wang, Ruolan, DeAnda, Felix, Johns, Brian A., Weaver, Kurt, Shen, Yingnian, Tomberlin, Ginger H., Carter, H. Luke, Broderick, Timothy, Sigethy, Scott, Seki, Takahiro, Kobayashi, Masanori, Underwood, Mark R.
Publicado em 2011

Antiviral Characteristics of GSK1265744, an HIV Integrase Inhibitor Dosed Orally or by Long-Acting Injection

Por Yoshinaga, Tomokazu, Kobayashi, Masanori, Seki, Takahiro, Miki, Shigeru, Wakasa-Morimoto, Chiaki, Suyama-Kagitani, Akemi, Kawauchi-Miki, Shinobu, Taishi, Teruhiko, Kawasuji, Takashi, Johns, Brian A., Underwood, Mark R., Garvey, Edward P., Sato, Akihiko, Fujiwara, Tamio
Publicado no Antimicrob Agents Chemother (2014)

In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor

Por Kobayashi, Masanori, Yoshinaga, Tomokazu, Seki, Takahiro, Wakasa-Morimoto, Chiaki, Brown, Kevin W., Ferris, Robert, Foster, Scott A., Hazen, Richard J., Miki, Shigeru, Suyama-Kagitani, Akemi, Kawauchi-Miki, Shinobu, Taishi, Teruhiko, Kawasuji, Takashi, Johns, Brian A., Underwood, Mark R., Garvey, Edward P., Sato, Akihiko, Fujiwara, Tamio
Publicado em 2011

Synthesis and Biological Evaluation of Macrocyclized Betulin Derivatives as a Novel Class of Anti-HIV-1 Maturation Inhibitors

Por Tang, Jun, Jones, Stacey A., Jeffery, Jerry L., Miranda, Sonia R., Galardi, Cristin M., Irlbeck, David M., Brown, Kevin W., McDanal, Charlene B., Han, Nianhe, Gao, Daxin, Wu, Yongyong, Shen, Bin, Liu, Chunyu, Xi, Caiming, Yang, Heping, Li, Rui, Yu, Yajun, Sun, Yufei, Jin, Zhimin, Wang, Erjuan, Johns, Brian A.
Publicado em 2014

The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral

Por Garvey, Edward P., Johns, Brian A., Gartland, Margaret J., Foster, Scott A., Miller, Wayne H., Ferris, Robert G., Hazen, Richard J., Underwood, Mark R., Boros, Eric E., Thompson, James B., Weatherhead, Jason G., Koble, Cecilia S., Allen, Scott H., Schaller, Lee T., Sherrill, Ronald G., Yoshinaga, Tomokazu, Kobayashi, Masanori, Wakasa-Morimoto, Chiaki, Miki, Shigeru, Nakahara, Koichiro, Noshi, Takeshi, Sato, Akihiko, Fujiwara, Tamio
Publicado em 2008

The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral

Por Garvey, Edward P., Johns, Brian A., Gartland, Margaret J., Foster, Scott A., Miller, Wayne H., Ferris, Robert G., Hazen, Richard J., Underwood, Mark R., Boros, Eric E., Thompson, James B., Weatherhead, Jason G., Koble, Cecilia S., Allen, Scott H., Schaller, Lee T., Sherrill, Ronald G., Yoshinaga, Tomokazu, Kobayashi, Masanori, Wakasa-Morimoto, Chiaki, Miki, Shigeru, Nakahara, Koichiro, Noshi, Takeshi, Sato, Akihiko, Fujiwara, Tamio
Publicado em 2008