The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral

The naphthyridinone GSK364735 potently inhibited recombinant human immunodeficiency virus type 1 (HIV-1) integrase in a strand transfer assay (mean 50% inhibitory concentration ± standard deviation, 8 ± 2 nM). As expected based on the structure of the drug, it bound competitively with another two-me...

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Autors principals: Garvey, Edward P., Johns, Brian A., Gartland, Margaret J., Foster, Scott A., Miller, Wayne H., Ferris, Robert G., Hazen, Richard J., Underwood, Mark R., Boros, Eric E., Thompson, James B., Weatherhead, Jason G., Koble, Cecilia S., Allen, Scott H., Schaller, Lee T., Sherrill, Ronald G., Yoshinaga, Tomokazu, Kobayashi, Masanori, Wakasa-Morimoto, Chiaki, Miki, Shigeru, Nakahara, Koichiro, Noshi, Takeshi, Sato, Akihiko, Fujiwara, Tamio
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258521/
https://ncbi.nlm.nih.gov/pubmed/18160521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01218-07
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