Antiviral Characteristics of GSK1265744, an HIV Integrase Inhibitor Dosed Orally or by Long-Acting Injection

GSK1265744 is a new HIV integrase strand transfer inhibitor (INSTI) engineered to deliver efficient antiviral activity with a once-daily, low-milligram dose that does not require a pharmacokinetic booster. The in vitro antiviral profile and mechanism of action of GSK1265744 were established through...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Yoshinaga, Tomokazu, Kobayashi, Masanori, Seki, Takahiro, Miki, Shigeru, Wakasa-Morimoto, Chiaki, Suyama-Kagitani, Akemi, Kawauchi-Miki, Shinobu, Taishi, Teruhiko, Kawasuji, Takashi, Johns, Brian A., Underwood, Mark R., Garvey, Edward P., Sato, Akihiko, Fujiwara, Tamio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291378/
https://ncbi.nlm.nih.gov/pubmed/25367908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03909-14
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