Hydroxylated Tropolones Inhibit Hepatitis B Virus Replication by Blocking Viral Ribonuclease H Activity

Hepatitis B virus (HBV) remains a major human pathogen despite the development of both antiviral drugs and a vaccine, in part because the current therapies do not suppress HBV replication far enough to eradicate the virus. Here, we screened 51 troponoid compounds for their ability to suppress HBV RN...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Lu, Gaofeng, Lomonosova, Elena, Cheng, Xiaohong, Moran, Eileen A., Meyers, Marvin J., Le Grice, Stuart F. J., Thomas, Craig J., Jiang, Jian-kang, Meck, Christine, Hirsch, Danielle R., D'Erasmo, Michael P., Suyabatmaz, Duygu M., Murelli, Ryan P., Tavis, John E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335860/
https://ncbi.nlm.nih.gov/pubmed/25451058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04617-14
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