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A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden
Postzygotic mutations in somatic cells lead to genome mosaicism and can be the cause of cancer, possibly other human diseases and aging. Somatic mutations are difficult to detect in bulk tissue samples. Here, we review the available assays for measuring somatic mutations, with a focus on recent sing...
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| Publicado no: | Exp Biol Med (Maywood) |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5529006/ https://ncbi.nlm.nih.gov/pubmed/28737476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370217717696 |
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