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Pathogenic mechanisms of somatic mutation and genome mosaicism in aging
Age-related accumulation of postzygotic DNA mutations results in tissue genetic heterogeneity known as somatic mosaicism. While implicated in aging as early as the 1950s, somatic mutations in normal tissues have been difficult to study because of their low allele fractions. With the recent emergence...
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| Veröffentlicht in: | Cell |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7354350/ https://ncbi.nlm.nih.gov/pubmed/32649873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.024 |
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