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Pathogenic mechanisms of somatic mutation and genome mosaicism in aging
Age-related accumulation of postzygotic DNA mutations results in tissue genetic heterogeneity known as somatic mosaicism. While implicated in aging as early as the 1950s, somatic mutations in normal tissues have been difficult to study because of their low allele fractions. With the recent emergence...
में बचाया:
| में प्रकाशित: | Cell |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7354350/ https://ncbi.nlm.nih.gov/pubmed/32649873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.024 |
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