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Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

Aging is a mysterious process, not only controlled genetically but also subject to random damage that can accumulate over time. While DNA damage and subsequent mutation in somatic cells were first proposed as drivers of aging more than 60 years ago, whether and to what degree these processes shape t...

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Bibliografski detalji
Izdano u:Hum Mol Genet
Glavni autori: Lodato, Michael A, Walsh, Christopher A
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872434/
https://ncbi.nlm.nih.gov/pubmed/31578549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz191
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