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Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

Aging is a mysterious process, not only controlled genetically but also subject to random damage that can accumulate over time. While DNA damage and subsequent mutation in somatic cells were first proposed as drivers of aging more than 60 years ago, whether and to what degree these processes shape t...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Lodato, Michael A, Walsh, Christopher A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872434/
https://ncbi.nlm.nih.gov/pubmed/31578549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz191
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