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Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

Accumulation of mutations in somatic cells has been implicated as a cause of aging since the 1950s. However, attempts to establish a causal relationship between somatic mutations and aging have been constrained by the lack of methods to directly identify mutational events in primary human tissues. H...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Zhang, Lei, Dong, Xiao, Lee, Moonsook, Maslov, Alexander Y., Wang, Tao, Vijg, Jan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500118/
https://ncbi.nlm.nih.gov/pubmed/30992375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902510116
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