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Accurate identification of single nucleotide variants in whole genome amplified single cells
Genome-wide, DNA mutation analysis in single cells is prone to artifacts associated with cell lysis and whole genome amplification. Here we addressed these issues by developing Single-Cell Multiple Displacement Amplification (SCMDA) and the single-cell variant caller, SCcaller. Validated by comparin...
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| Publicat a: | Nat Methods |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5408311/ https://ncbi.nlm.nih.gov/pubmed/28319112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4227 |
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