Accurate identification of single nucleotide variants in whole genome amplified single cells

Genome-wide, DNA mutation analysis in single cells is prone to artifacts associated with cell lysis and whole genome amplification. Here we addressed these issues by developing Single-Cell Multiple Displacement Amplification (SCMDA) and the single-cell variant caller, SCcaller. Validated by comparin...

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Vydáno v:Nat Methods
Hlavní autoři: Dong, Xiao, Zhang, Lei, Milholland, Brandon, Lee, Moonsook, Maslov, Alexander Y., Wang, Tao, Vijg, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408311/
https://ncbi.nlm.nih.gov/pubmed/28319112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4227
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