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Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants
DNA mutations are the source of genetic variation within populations. The majority of mutations with observable effects are deleterious. In humans mutations in the germ line can cause genetic disease. In somatic cells multiple rounds of mutations and selection lead to cancer. The study of genetic va...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237897/ https://ncbi.nlm.nih.gov/pubmed/22016070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2011.10.001 |
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