Stabilization of Glucocerebrosidase by Active Site Occupancy

[Image: see text] Glucocerebrosidase (GBA) is a lysosomal β-glucosidase that degrades glucosylceramide. Its deficiency results in Gaucher disease (GD). We examined the effects of active site occupancy of GBA on its structural stability. For this, we made use of cyclophellitol-derived activity-based...

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I publikationen:ACS Chem Biol
Huvudupphovsmän: Ben Bdira, Fredj, Kallemeijn, Wouter W., Oussoren, Saskia V., Scheij, Saskia, Bleijlevens, Boris, Florea, Bogdan I., van Roomen, Cindy P. A. A., Ottenhoff, Roelof, van Kooten, Marielle J. F. M., Walvoort, Marthe T. C., Witte, Martin D., Boot, Rolf G., Ubbink, Marcellus, Overkleeft, Herman S., Aerts, Johannes M. F. G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2017
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525105/
https://ncbi.nlm.nih.gov/pubmed/28485919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00276
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