Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity

Prions, characterized by self-propagating protease-resistant prion protein (PrP) conformations, are agents causing prion disease. Recent studies generated several such self-propagating protease-resistant recombinant PrP (rPrP-res) conformers. While some cause prion disease, others fail to induce any...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Wang, Fei, Wang, Xinhe, Orrú, Christina D., Groveman, Bradley R., Surewicz, Krystyna, Abskharon, Romany, Imamura, Morikazu, Yokoyama, Takashi, Kim, Yong-Sun, Vander Stel, Kayla J., Sinniah, Kumar, Priola, Suzette A., Surewicz, Witold K., Caughey, Byron, Ma, Jiyan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524416/
https://ncbi.nlm.nih.gov/pubmed/28704563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006491
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