Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers

The self-induced formation of the disease-associated, protease-resistant prion protein (PrP-res) from the normal protease-sensitive isoform (PrP-sen) appears to be a key event in the pathogenesis of transmissible spongiform encephalopathies. The amino acid sequence specificity of PrP-res formation c...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Horiuchi, Motohiro, Priola, Suzette A., Chabry, Joëlle, Caughey, Byron
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18520/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110523897
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