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Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers

The self-induced formation of the disease-associated, protease-resistant prion protein (PrP-res) from the normal protease-sensitive isoform (PrP-sen) appears to be a key event in the pathogenesis of transmissible spongiform encephalopathies. The amino acid sequence specificity of PrP-res formation c...

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Autori principali: Horiuchi, Motohiro, Priola, Suzette A., Chabry, Joëlle, Caughey, Byron
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC18520/
https://ncbi.nlm.nih.gov/pubmed/10811921
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