Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

Scrapie is a transmissible neurodegenerative disease that appears to result from an accumulation in the brain of an abnormal protease-resistant isoform of prion protein (PrP) called PrPsc. Conversion of the normal, protease-sensitive form of PrP (PrPc) to protease-resistant forms like PrPsc has been...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kocisko, D A, Priola, S A, Raymond, G J, Chesebro, B, Lansbury, P T, Caughey, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42074/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7732006/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3923
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