Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

Scrapie is a transmissible neurodegenerative disease that appears to result from an accumulation in the brain of an abnormal protease-resistant isoform of prion protein (PrP) called PrPsc. Conversion of the normal, protease-sensitive form of PrP (PrPc) to protease-resistant forms like PrPsc has been...

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Detalhes bibliográficos
Main Authors: Kocisko, D A, Priola, S A, Raymond, G J, Chesebro, B, Lansbury, P T, Caughey, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC42074/
https://ncbi.nlm.nih.gov/pubmed/7732006
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