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Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state.
In the transmissible spongiform encephalopathies, normal prion protein (PrP-sen) is converted to a protease-resistant isoform, PrP-res, by an apparent self-propagating activity of the latter. Here we describe new, more physiological cell-free systems for analyzing the initial binding and subsequent...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1999
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171400/ https://ncbi.nlm.nih.gov/pubmed/10369660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.12.3193 |
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