Recombinant Human Prion Protein Inhibits Prion Propagation in vitro

Prion diseases are associated with the conformational conversion of the cellular prion protein (PrP(C)) into the pathological scrapie isoform (PrP(Sc)) in the brain. Both the in vivo and in vitro conversion of PrP(C) into PrP(Sc) is significantly inhibited by differences in amino acid sequence betwe...

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Detalhes bibliográficos
Main Authors: Yuan, Jue, Zhan, Yi-An, Abskharon, Romany, Xiao, Xiangzhu, Martinez, Manuel Camacho, Zhou, Xiaochen, Kneale, Geoff, Mikol, Jacqueline, Lehmann, Sylvain, Surewicz, Witold K., Castilla, Joaquín, Steyaert, Jan, Zhang, Shulin, Kong, Qingzhong, Petersen, Robert B., Wohlkonig, Alexandre, Zou, Wen-Quan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793212/
https://ncbi.nlm.nih.gov/pubmed/24105336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02911
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