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Nucleation-dependent conformational conversion of the Y145Stop variant of human prion protein: Structural clues for prion propagation

One of the most intriguing disease-related mutations in human prion protein (PrP) is the Tyr to Stop codon substitution at position 145. This mutation results in a Gerstmann–Straussler–Scheinker-like disease with extensive PrP amyloid deposits in the brain. Here, we provide evidence for a spontaneou...

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Bibliografiske detaljer
Main Authors: Kundu, Bishwajit, Maiti, Nilesh R., Jones, Eric M., Surewicz, Krystyna A., Vanik, David L., Surewicz, Witold K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC218714/
https://ncbi.nlm.nih.gov/pubmed/14519851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2033281100
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