Conformational Flexibility of Y145Stop Human Prion Protein Amyloid Fibrils Probed by Solid-State Nuclear Magnetic Resonance Spectroscopy

Amyloid aggregates of a C-truncated Y145Stop mutant of human prion protein, huPrP23-144, associated with a heritable amyloid angiopathy, have previously been shown to contain a compact, relatively rigid and β-sheet-rich ∼30-residue amyloid core near the C-terminus under physiologically relevant cond...

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Bibliographic Details
Main Authors: Helmus, Jonathan J., Surewicz, Krystyna, Surewicz, Witold K., Jaroniec, Christopher P.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838504/
https://ncbi.nlm.nih.gov/pubmed/20121096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja909827v
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