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Intermolecular Alignment in Y145Stop Human Prion Protein Amyloid Fibrils Probed by Solid-State NMR Spectroscopy

The Y145Stop mutant of human prion protein, huPrP23-144, has been linked to PrP cerebral amyloid angiopathy, an inherited amyloid disease, and also serves as a valuable in vitro model for investigating the molecular basis of amyloid strains. Prior studies of huPrP23-144 amyloid by magic-angle spinni...

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Main Authors: Helmus, Jonathan J., Surewicz, Krystyna, Apostol, Marcin I., Surewicz, Witold K., Jaroniec, Christopher P.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164902/
https://ncbi.nlm.nih.gov/pubmed/21827207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja206469q
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