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Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils

A C-terminally truncated Y145Stop variant of the human prion protein (huPrP23–144) is associated with a hereditary amyloid disease known as PrP cerebral amyloid angiopathy. Previous studies have shown that recombinant huPrP23–144 can be efficiently converted in vitro to the fibrillar amyloid state,...

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Detalhes bibliográficos
Main Authors: Helmus, Jonathan J., Surewicz, Krystyna, Nadaud, Philippe S., Surewicz, Witold K., Jaroniec, Christopher P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359773/
https://ncbi.nlm.nih.gov/pubmed/18436646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711716105
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