Structural Polymorphism in Amyloids: NEW INSIGHTS FROM STUDIES WITH Y145Stop PRION PROTEIN FIBRILS

The C-terminally-truncated human prion protein variant Y145Stop (or PrP23–144), associated with a familial prion disease, provides a valuable model for studying the fundamental properties of protein amyloids. In previous solid-state NMR experiments, we established that the β-sheet core of the PrP23–...

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Detalhes bibliográficos
Main Authors: Jones, Eric M., Wu, Bo, Surewicz, Krystyna, Nadaud, Philippe S., Helmus, Jonathan J., Chen, Shugui, Jaroniec, Christopher P., Surewicz, Witold K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234922/
https://ncbi.nlm.nih.gov/pubmed/22002245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.302539
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