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Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils
A C-terminally truncated Y145Stop variant of the human prion protein (huPrP23–144) is associated with a hereditary amyloid disease known as PrP cerebral amyloid angiopathy. Previous studies have shown that recombinant huPrP23–144 can be efficiently converted in vitro to the fibrillar amyloid state,...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2359773/ https://ncbi.nlm.nih.gov/pubmed/18436646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711716105 |
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