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Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages
Degradation of lysosomal lipids requires lysosomal acid lipase (LAL), the only intracellular lipase known to be active at acidic pH. We found LAL to be expressed in murine immune cells with highest mRNA expression in macrophages and neutrophils. Furthermore, we observed that loss of LAL in mice caus...
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| Veröffentlicht in: | Oncotarget |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Impact Journals LLC
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5522325/ https://ncbi.nlm.nih.gov/pubmed/28402950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16673 |
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