Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages

Degradation of lysosomal lipids requires lysosomal acid lipase (LAL), the only intracellular lipase known to be active at acidic pH. We found LAL to be expressed in murine immune cells with highest mRNA expression in macrophages and neutrophils. Furthermore, we observed that loss of LAL in mice caus...

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Vydáno v:Oncotarget
Hlavní autoři: Schlager, Stefanie, Vujic, Nemanja, Korbelius, Melanie, Duta-Mare, Madalina, Dorow, Juliane, Leopold, Christina, Rainer, Silvia, Wegscheider, Martin, Reicher, Helga, Ceglarek, Uta, Sattler, Wolfgang, Radovic, Branislav, Kratky, Dagmar
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper: Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522325/
https://ncbi.nlm.nih.gov/pubmed/28402950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16673
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