Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages

Degradation of lysosomal lipids requires lysosomal acid lipase (LAL), the only intracellular lipase known to be active at acidic pH. We found LAL to be expressed in murine immune cells with highest mRNA expression in macrophages and neutrophils. Furthermore, we observed that loss of LAL in mice caus...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Schlager, Stefanie, Vujic, Nemanja, Korbelius, Melanie, Duta-Mare, Madalina, Dorow, Juliane, Leopold, Christina, Rainer, Silvia, Wegscheider, Martin, Reicher, Helga, Ceglarek, Uta, Sattler, Wolfgang, Radovic, Branislav, Kratky, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper: Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522325/
https://ncbi.nlm.nih.gov/pubmed/28402950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16673
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