P53 suppresses ribonucleotide reductase via inhibiting mTORC1

Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2 (RRM2) via inhibiting mammalia...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: He, Zhengfu, Hu, Xing, Liu, Weijin, Dorrance, Adrienne, Garzon, Ramiro, Houghton, Peter J., Shen, Changxian
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522210/
https://ncbi.nlm.nih.gov/pubmed/28507282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17440
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