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P53 suppresses ribonucleotide reductase via inhibiting mTORC1
Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2 (RRM2) via inhibiting mammalia...
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| 發表在: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Impact Journals LLC
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5522210/ https://ncbi.nlm.nih.gov/pubmed/28507282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17440 |
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