mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer()()

Ribonucleotide reductase (RNR) is the key enzyme that catalyzes the production of deoxyribonucleotides (dNTPs) for DNA replication and it is also essential for cancer cell proliferation. As the RNR inhibitor, Gemcitabine is widely used in cancer therapies, however, resistance limits its therapeutic...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Tian, Ling, Chen, Congcong, Guo, Yanguan, Zhang, Fan, Mi, Jinye, Feng, Qi, Lin, Shengbin, Xi, Naite, Tian, Jiaxin, Yu, Li, Chen, Yan, Cao, Mingrong, Lai, Caiyong, Fan, Jun, Zhang, Yongchang, Chen, Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215139/
https://ncbi.nlm.nih.gov/pubmed/34126361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2021.05.007
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