mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer()()

Ribonucleotide reductase (RNR) is the key enzyme that catalyzes the production of deoxyribonucleotides (dNTPs) for DNA replication and it is also essential for cancer cell proliferation. As the RNR inhibitor, Gemcitabine is widely used in cancer therapies, however, resistance limits its therapeutic...

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Dettagli Bibliografici
Pubblicato in:Neoplasia
Autori principali: Tian, Ling, Chen, Congcong, Guo, Yanguan, Zhang, Fan, Mi, Jinye, Feng, Qi, Lin, Shengbin, Xi, Naite, Tian, Jiaxin, Yu, Li, Chen, Yan, Cao, Mingrong, Lai, Caiyong, Fan, Jun, Zhang, Yongchang, Chen, Guo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2021
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215139/
https://ncbi.nlm.nih.gov/pubmed/34126361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2021.05.007
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