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Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells
Oncogenic transformation leads to dysregulated cell proliferation, nutrient deficiency, and hypoxia resulting in metabolic stress and increased DNA damage. In normal cells, such metabolic stress leads to inhibition of signaling through the mammalian Target of Rapamycin Complex 1 (mTORC1), reduction...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5431544/ https://ncbi.nlm.nih.gov/pubmed/28484242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01729-w |
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