Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules

Fibrillar aggregates of the protein α-synuclein (αS) are one of the hallmarks of Parkinson’s disease. Here, we show that measuring the fluorescence polarization (FP) of labels at several sites on αS allows one to monitor changes in the local dynamics of the protein after binding to micelles or vesic...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Haney, Conor M., Cleveland, Christina L., Wissner, Rebecca F., Owei, Lily, Robustelli, Jaclyn, Daniels, Malcolm, Canyurt, Merve, Rodriguez, Priscilla, Ischiropoulos, Harry, Baumgart, Tobias, Petersson, E. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520965/
https://ncbi.nlm.nih.gov/pubmed/28045494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01060
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