Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules

Fibrillar aggregates of the protein α-synuclein (αS) are one of the hallmarks of Parkinson’s disease. Here, we show that measuring the fluorescence polarization (FP) of labels at several sites on αS allows one to monitor changes in the local dynamics of the protein after binding to micelles or vesic...

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Bibliografiset tiedot
Julkaisussa:Biochemistry
Päätekijät: Haney, Conor M., Cleveland, Christina L., Wissner, Rebecca F., Owei, Lily, Robustelli, Jaclyn, Daniels, Malcolm, Canyurt, Merve, Rodriguez, Priscilla, Ischiropoulos, Harry, Baumgart, Tobias, Petersson, E. James
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520965/
https://ncbi.nlm.nih.gov/pubmed/28045494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01060
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