Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules

Fibrillar aggregates of the protein α-synuclein (αS) are one of the hallmarks of Parkinson’s disease. Here, we show that measuring the fluorescence polarization (FP) of labels at several sites on αS allows one to monitor changes in the local dynamics of the protein after binding to micelles or vesic...

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Udgivet i:Biochemistry
Main Authors: Haney, Conor M., Cleveland, Christina L., Wissner, Rebecca F., Owei, Lily, Robustelli, Jaclyn, Daniels, Malcolm, Canyurt, Merve, Rodriguez, Priscilla, Ischiropoulos, Harry, Baumgart, Tobias, Petersson, E. James
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520965/
https://ncbi.nlm.nih.gov/pubmed/28045494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01060
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