Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules

Fibrillar aggregates of the protein α-synuclein (αS) are one of the hallmarks of Parkinson’s disease. Here, we show that measuring the fluorescence polarization (FP) of labels at several sites on αS allows one to monitor changes in the local dynamics of the protein after binding to micelles or vesic...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Haney, Conor M., Cleveland, Christina L., Wissner, Rebecca F., Owei, Lily, Robustelli, Jaclyn, Daniels, Malcolm, Canyurt, Merve, Rodriguez, Priscilla, Ischiropoulos, Harry, Baumgart, Tobias, Petersson, E. James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520965/
https://ncbi.nlm.nih.gov/pubmed/28045494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01060
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