GINSENOSIDE RB1 INHIBITS FIBRILLATION AND TOXICITY OF ALPHA-SYNUCLEIN AND DISAGGREGATES PREFORMED FIBRILS

Compelling evidence indicates that α-synuclein (α-syn) aggregation plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. Identification of compounds that inhibit or reverse the aggregation process may thus represent a viable therapeutic strategy again...

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Pubblicato in:Neurobiol Dis
Autori principali: Ardah, Mustafa T., Paleologou, Katerina E., Lv, Guohua, Menon, Sindhu A., Khair, Salema B. Abul, Lu, Jia-Hong, Safieh-Garabedian, Bared, Al-Hayani, Abdulmonem A., Eliezer, David, Li, Min, El-Agnaf, Omar MA.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882765/
https://ncbi.nlm.nih.gov/pubmed/25449909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.11.007
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