Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress

Alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect cellular responses in multiple conditions, yet the underlying mechanisms are incompletely understood. Here we report that autophagy receptor p62/sequestosome-1 interacts with E2 Ub conjugating enzymes, UBE2D2...

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Dettagli Bibliografici
Pubblicato in:Cell Res
Autori principali: Peng, Hong, Yang, Jiao, Li, Guangyi, You, Qing, Han, Wen, Li, Tianrang, Gao, Daming, Xie, Xiaoduo, Lee, Byung-Hoon, Du, Juan, Hou, Jian, Zhang, Tao, Rao, Hai, Huang, Ying, Li, Qinrun, Zeng, Rong, Hui, Lijian, Wang, Hongyan, Xia, Qin, Zhang, Xuemin, He, Yongning, Komatsu, Masaaki, Dikic, Ivan, Finley, Daniel, Hu, Ronggui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520855/
https://ncbi.nlm.nih.gov/pubmed/28322253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.40
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