Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro

AIM: To investigate whether sequestosome 1/p62 (p62), a key cargo adaptor protein involved in both the ubiquitin-proteasome system and the autophagy-lysosome system, could directly regulate autophagy in vitro. METHODS: HEK 293 cells or HeLa cells were transfected with p62-expressing plasmids or siRN...

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Detalhes bibliográficos
Main Authors: Zhou, Liang, Wang, Hong-feng, Ren, Hai-gang, Chen, Dong, Gao, Feng, Hu, Qing-song, Fu, Chen, Xu, Ran-jie, Ying, Zheng, Wang, Guang-hui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647217/
https://ncbi.nlm.nih.gov/pubmed/23564079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.12
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