Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress

Alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect cellular responses in multiple conditions, yet the underlying mechanisms are incompletely understood. Here we report that autophagy receptor p62/sequestosome-1 interacts with E2 Ub conjugating enzymes, UBE2D2...

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Publicat a:Cell Res
Autors principals: Peng, Hong, Yang, Jiao, Li, Guangyi, You, Qing, Han, Wen, Li, Tianrang, Gao, Daming, Xie, Xiaoduo, Lee, Byung-Hoon, Du, Juan, Hou, Jian, Zhang, Tao, Rao, Hai, Huang, Ying, Li, Qinrun, Zeng, Rong, Hui, Lijian, Wang, Hongyan, Xia, Qin, Zhang, Xuemin, He, Yongning, Komatsu, Masaaki, Dikic, Ivan, Finley, Daniel, Hu, Ronggui
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520855/
https://ncbi.nlm.nih.gov/pubmed/28322253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.40
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