Monoclonal iNKT cell mice reveal a role for both tissue of origin and the TCR in development of iNKT functional subsets

iNKT cell functional subsets are defined by key transcription factors and output of cytokines such as IL-4, IFNγ, IL-17, and IL-10. To examine how TCR specificity determines iNKT function, we used somatic cell nuclear transfer to generate three lines of mice, cloned from iNKT nuclei. Each line uses...

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Xehetasun bibliografikoak
Argitaratua izan da:J Immunol
Egile Nagusiak: Clancy-Thompson, Eleanor, Chen, Gui Zhen, Tyler, Paul M., Servos, Mariah M., Barisa, Marta, Brennan, Patrick J., Ploegh, Hidde L., Dougan, Stephanie K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518629/
https://ncbi.nlm.nih.gov/pubmed/28576977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700214
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