Monoclonal iNKT cell mice reveal a role for both tissue of origin and the TCR in development of iNKT functional subsets

iNKT cell functional subsets are defined by key transcription factors and output of cytokines such as IL-4, IFNγ, IL-17, and IL-10. To examine how TCR specificity determines iNKT function, we used somatic cell nuclear transfer to generate three lines of mice, cloned from iNKT nuclei. Each line uses...

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Veröffentlicht in:J Immunol
Hauptverfasser: Clancy-Thompson, Eleanor, Chen, Gui Zhen, Tyler, Paul M., Servos, Mariah M., Barisa, Marta, Brennan, Patrick J., Ploegh, Hidde L., Dougan, Stephanie K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518629/
https://ncbi.nlm.nih.gov/pubmed/28576977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700214
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