TCR signal strength controls thymic differentiation of iNKT cell subsets

During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development of iNKT cell subsets, with strong signaling promot...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tuttle, Kathryn D., Krovi, S. Harsha, Zhang, Jingjing, Bedel, Romain, Harmacek, Laura, Peterson, Lisa K., Dragone, Leonard L., Lefferts, Adam, Halluszczak, Catherine, Riemondy, Kent, Hesselberth, Jay R., Rao, Anjana, O’Connor, Brian P., Marrack, Philippa, Scott-Browne, James, Gapin, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037704/
https://ncbi.nlm.nih.gov/pubmed/29985393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05026-6
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