TCR signal strength controls thymic differentiation of iNKT cell subsets

During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development of iNKT cell subsets, with strong signaling promot...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Tuttle, Kathryn D., Krovi, S. Harsha, Zhang, Jingjing, Bedel, Romain, Harmacek, Laura, Peterson, Lisa K., Dragone, Leonard L., Lefferts, Adam, Halluszczak, Catherine, Riemondy, Kent, Hesselberth, Jay R., Rao, Anjana, O’Connor, Brian P., Marrack, Philippa, Scott-Browne, James, Gapin, Laurent
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037704/
https://ncbi.nlm.nih.gov/pubmed/29985393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05026-6
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