TCR signal strength controls thymic differentiation of iNKT cell subsets

During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development of iNKT cell subsets, with strong signaling promot...

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Pubblicato in:Nat Commun
Autori principali: Tuttle, Kathryn D., Krovi, S. Harsha, Zhang, Jingjing, Bedel, Romain, Harmacek, Laura, Peterson, Lisa K., Dragone, Leonard L., Lefferts, Adam, Halluszczak, Catherine, Riemondy, Kent, Hesselberth, Jay R., Rao, Anjana, O’Connor, Brian P., Marrack, Philippa, Scott-Browne, James, Gapin, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037704/
https://ncbi.nlm.nih.gov/pubmed/29985393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05026-6
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