Monoclonal iNKT cell mice reveal a role for both tissue of origin and the TCR in development of iNKT functional subsets

iNKT cell functional subsets are defined by key transcription factors and output of cytokines such as IL-4, IFNγ, IL-17, and IL-10. To examine how TCR specificity determines iNKT function, we used somatic cell nuclear transfer to generate three lines of mice, cloned from iNKT nuclei. Each line uses...

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Gepubliceerd in:J Immunol
Hoofdauteurs: Clancy-Thompson, Eleanor, Chen, Gui Zhen, Tyler, Paul M., Servos, Mariah M., Barisa, Marta, Brennan, Patrick J., Ploegh, Hidde L., Dougan, Stephanie K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518629/
https://ncbi.nlm.nih.gov/pubmed/28576977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700214
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