Mutant lac repressors with new specificities hint at rules for protein--DNA recognition.

Proteins which recognize specific sequences of DNA play a fundamental role in the regulation of protein synthesis in all organisms. A particular helix of the bacterial protein lac repressor recognizes the bases in the major groove of the lac operator. We show that the first two residues of this reco...

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Bibliographic Details
Main Authors: Lehming, N, Sartorius, J, Kisters-Woike, B, von Wilcken-Bergmann, B, Müller-Hill, B
Format: Artigo
Language:Inglês
Published: 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC551714/
https://ncbi.nlm.nih.gov/pubmed/2178920
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