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Extended Two-stage Adaptive Designs with Three Target Responses for Phase II Clinical Trials

We develop a nature-inspired stochastic population-based algorithm and call it discrete particle swarm optimization (DPSO) to find extended two-stage adaptive optimal designs that allow 3 target response rates for the drug in a phase II trial. Our proposed designs include the celebrated Simon’s two-...

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Publicat a:Stat Methods Med Res
Autors principals: Kim, Seongho, Wong, Weng Kee
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515697/
https://ncbi.nlm.nih.gov/pubmed/28535716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280217709817
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