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Optimal adaptive two-stage designs for early Phase II clinical trials
Simon’s optimal two-stage design has been widely used in early phase clinical trials for Oncology and AIDS studies with binary endpoints. With this approach, the second stage sample size is fixed when the trial passes the first stage with sufficient activity. Adaptive designs, such as those due to B...
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| Опубликовано в: : | Stat Med |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777673/ https://ncbi.nlm.nih.gov/pubmed/26526165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6794 |
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