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Optimal adaptive two-stage designs for early Phase II clinical trials

Simon’s optimal two-stage design has been widely used in early phase clinical trials for Oncology and AIDS studies with binary endpoints. With this approach, the second stage sample size is fixed when the trial passes the first stage with sufficient activity. Adaptive designs, such as those due to B...

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Bibliographische Detailangaben
Veröffentlicht in:Stat Med
Hauptverfasser: Shan, Guogen, Wilding, Gregory, Hutson, Alan, Gerstenberger, Shawn
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777673/
https://ncbi.nlm.nih.gov/pubmed/26526165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6794
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