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Two-stage optimal designs with survival endpoint when the follow-up time is restricted
BACKGROUND: Survival endpoint is frequently used in early phase clinical trials as the primary endpoint to assess the activity of a new treatment. Existing two-stage optimal designs with survival endpoint either over estimate the sample size or compute power outside the alternative hypothesis space....
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| Publicado no: | BMC Med Res Methodol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6448233/ https://ncbi.nlm.nih.gov/pubmed/30943896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-019-0696-x |
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